Phosphatidylserine in MemoFix: Dose, Role & Evidence

Phosphatidylserine is one of the less flashy ingredients in the formula, but it's also one where the biological role is unusually well established.

What it is

Phosphatidylserine is a phospholipid — a type of fat molecule that forms a structural component of cell membranes. It's particularly concentrated in brain tissue, where it makes up a meaningful share of the brain's total phospholipid content.

Why membrane integrity matters for cognition

Neurons communicate through signals that cross their cell membranes. The composition and fluidity of those membranes affects how efficiently that signaling happens, which is the mechanistic basis for including phosphatidylserine in a cognitive formula. It's also involved in supporting neurotransmitter release.

What the research shows

Phosphatidylserine has been studied for memory and cognitive processing, with several trials in older adults reporting modest improvements in memory-related measures. The evidence is more developed in age-related cognitive decline contexts than in healthy young adults, where results are less clear.

About the 150mg dose

Clinical research on phosphatidylserine has often used doses around 100–300mg daily, so 150mg sits within — though toward the lower half of — the studied range.

A sourcing note

Phosphatidylserine used to be derived from bovine brain tissue; modern supplements almost universally use soy or sunflower-derived versions, which avoids the safety concerns associated with the older sourcing method. If you have a soy sensitivity, that's worth checking on the specific product label.

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